Rapid Normalization of High Glutamic Acid Decarboxylase Autoantibody Titers and Preserved Endogenous Insulin Secretion in a Patient with Diabetes Mellitus: A Case Report and Literature Review

Author:

Ohara Nobumasa12,Kaneko Masanori12,Furukawa Tatsuo3,Koike Tadashi3,Sone Hirohito2,Tanaka Shoichiro4,Kaneko Kenzo1,Kamoi Kyuzi5

Affiliation:

1. Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan

2. Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Japan

3. Department of Hematology, Nagaoka Red Cross Hospital, Japan

4. Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan

5. Center of Diabetes, Endocrinology and Metabolism, Joetsu General Hospital, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference16 articles.

1. 1. Seino Y, Nanjo K, Tajima N, et al; Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig 1: 212-228, 2010.

2. 2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 37 (Suppl 1): S81-S90, 2014.

3. 3. Winter WE, Schatz DA. Autoimmune markers in diabetes. Clin Chem 57: 168-175, 2011.

4. 4. Niregi E, Nagasaka S, Tomizawa Y, et al. A case of diabetes mellitus, in whom anti-GAD antibody turned into negative within 2 years of period, remaining still non-insulin dependent. Tonyobyo (J Jpn Diab Soc) 49: 717-721, 2006 (in Japanese).

5. 5. Wada M, Nishiki M. Slowly progressive type 1 diabetes mellitus showing negative conversion of anti-glutamic acid decarboxylase antibody within 10 months in an elderly patient. Shimane Igaku (J Shimane M A) 27: 303-307, 2007 (In Japanese).

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