A Phase II Study of Tailored-dose S-1 Plus Carboplatin Followed by Maintenance S-1 for Advanced Squamous Cell Lung Cancer: OSAKA-LCSG 1102

Author:

Yokoi Takashi12,Minami Seigo3,Shiroyama Takayuki4,Koba Taro35,Torii Yoshitaro1,Sugimoto Hiroyuki1,Niki Maiko1,Mori Masahide6,Morimura Osamu5,Hirashima Tomonori4,Komuta Kiyoshi3,Kijima Takashi25

Affiliation:

1. Department of Thoracic Oncology, Kansai Medical University Hospital, Japan

2. Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Japan

3. Department of Respiratory Medicine, Osaka Police Hospital, Japan

4. Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan

5. Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Japan

6. Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference11 articles.

1. 1. Ohe Y, Ohashi Y, Kubota K, et al. Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol 18: 317-323, 2007.

2. 2. Shirasaka T, Nakano K, Takechi T, et al. Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats. Cancer Res 56: 2602-2606, 1996.

3. 3. Okamoto I, Fukuoka M. S-1: a new oral fluoropyrimidine in the treatment of patients with advanced non-small-cell lung cancer. Clin Lung Cancer 10: 290-294, 2009.

4. 4. Okamoto I, Yoshioka H, Morita S, et al. Phase III trial comparing oral S-1 plus carboplatin with paclitaxel plus carboplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer: results of a west Japanoncology group study. J Clin Oncol 28: 5240-5246, 2010.

5. 5. Yoshioka H, Okamoto I, Morita S, et al. Efficacy and safety analysis according to histology for S-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell lung cancer: updated results of the West Japan OncologyGroup LETS study. Ann Oncol 24: 1326-1331, 2013.

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