The Long-term Outcomes after VAD plus SCT Therapy in a Patient with AL Amyloidosis and Severe Factor X Deficiency

Author:

Iwadate Dosuke1,Hasegawa Eiko1,Hoshino Junichi1,Hayami Noriko1,Sumida Keiichi1,Yamanouchi Masayuki1,Sekine Akinari1,Kawada Masahiro1,Hiramatsu Rikako1,Suwabe Tatsuya1,Sawa Naoki1,Yuasa Mitsuhiro2,Wake Atsushi2,Fujii Takeshi3,Ohashi Kenichi34,Takaichi Kenmei15,Ubara Yoshifumi15

Affiliation:

1. Nephrology Center, Toranomon Hospital, Japan

2. Department of Hematology, Toranomon Hospital, Japan

3. Department of Pathology, Toranomon Hospital, Japan

4. Department of Pathology, Yokohama City University, Graduate School of Medicine, Japan

5. Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference12 articles.

1. 1. Sipe JD, Benson MD, Buxbaum JN, et al. Nomenclature 2014: amyloid fibril proteins and clinical classification of the amyloidosis. Amyloid 21: 221-224, 2014.

2. 2. Gertz MA, Dispenzieri A. Immunoglobulin light-chain amyloidosis: growing recognition, new approaches to therapy, active clinical trials. Oncology (Williston Park) 26: 152-161, 2012.

3. 3. Wechalekar AD, Gillmore JD, Hawkins PN. Systemic amyloidosis. Lancet 387: 2641-2654, 2016.

4. 4. Perz JB, Schonland SO, Hundemer M, et al. High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis:a single centre prospective phase II study. Br J Haematol 127: 543-551, 2004.

5. 5. Choufani EB, Sanchorawala V, Ernst T, et al. Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapy. Blood 97: 1885-1887, 2001.

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