Role of NS5A-L31/Y93 Double Wild-type in Failure of Glecaprevir/Pibrentasvir Double Therapy in Two Patients with a History of Direct-acting Antiviral Agent Failure: An Ultra-deep Sequencing Analysis
Author:
Affiliation:
1. Department of Hepatology, Toranomon Hospital, Japan
2. Liver Research Laboratory, Toranomon Hospital, Japan
Publisher
Japanese Society of Internal Medicine
Subject
General Medicine,Internal Medicine
Link
https://www.jstage.jst.go.jp/article/internalmedicine/58/18/58_2604-18/_pdf
Reference13 articles.
1. 1. Ng TI, Krishnan P, Pilot-Matias T, et al. In vitro antiviral activity and resistance profile of the next-generation hepatitis C virus NS5A inhibitor pibrentasvir. Antimicrob Agents Chemother 61: e02558, 2017.
2. 2. Ng T, Tripathi R, Dekyhyar T, et al. In vitro antiviral activity and resistance profile of the next-generation hepatitis C virus NS3-4A protease inhibitor glecaprevir. Antimicrob Agents Chemother 62: e01620, 2017.
3. 3. Kato N, Hijikata M, Ootsuyama Y, et al. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci USA 87: 9524-9528.
4. 4. McPhee F, Hernandez D, Zhou N, et al. Virological escape in HCV genotype-1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b. Antivir Ther 19: 479-490, 2014.
5. 5. Pawlotsky JM. Hepatitis C virus resistance to direct-acting antiviral drugs in interferon-free regimens. Gastroenterology 151: 70-86, 2016.
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