Inflammatory Cerebellar PML with a CD4/CD8 Ratio of 2.9 Showed a Favorable Prognosis in a Patient with Rheumatoid Arthritis

Author:

Nishigori Ryusei12,Warabi Yoko1,Shishido-Hara Yukiko34,Nakamichi Kazuo5,Nakata Yasuhiro6,Komori Takashi7,Isozaki Eiji1

Affiliation:

1. Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan

2. Department of Neurology, Kyoto University Graduate School of Medicine, Japan

3. Department of Anatomic Pathology, Tokyo Medical University, Japan

4. Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Japan

5. Department of Virology 1, National Institute of Infectious Diseases, Japan

6. Department of Neuroradiology, Tokyo Metropolitan Neurological Hospital, Japan

7. Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference15 articles.

1. 1. Berger JR, Cree BA, Greenberg B, et al. Progressive multifocal leukoencephalopathy after fingolimod treatment. Neurology 90: e1815-e1821, 2018.

2. 2. Nishiyama S, Misu T, Shishido-Hara Y, et al. Fingolimod-associated PML with mild IRIS in MS: a clinicopathologic study. Neurol Neuroimmunol Neuroinflamm 5: e415, 2018.

3. 3. Ishii J, Shishido-Hara Y, Kawamoto M, et al. A punctate magnetic resonance imaging pattern in a patient with systemic lupus erythematosus is an early sign of progressive multifocal leukoencephalopathy: a clinicopathological study. Intern Med 57: 2727-2734, 2018.

4. 4. Wattjes MP, Wijburg MT, Vennegoor A, et al. MRI characteristics of early PML-IRIS after natalizumab treatment in patients with MS. J Neurol Neurosurg Psychiatry 87: 879-884, 2016.

5. 5. Metz I, Radue EW, Oterino A, et al. Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy. Acta Neuropathol 123: 235-245, 2012.

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