DAMMARANE TRITERPENE, FLAVONE GLYCOSIDES FROM THE STEMS AND LEAVES OF CHISOCHETON PANICULATUS HIERN (MELIACEAE)

Author:

Nguyen Thi Hoai1,Nguyen Thi Xuan Hoa2,Le Tuan Anh3,Do Thi Thao4,Vo Quoc Hung1,Hoang Xuan Huyen Trang1,Le Thi Bich Hien1,Ho Viet Duc1

Affiliation:

1. Hue University of Medicine and Pharmacy, Hue University

2. Department of Technology Science and Training, Ministry of Health

3. Central Vietnam Institute for Scientific Research

4. Institute of Biotechnology, VAST

Abstract

Background: Chisocheton Blume is the second largest genus in the Meliaceae family. In Viet Nam, this genus consists of three species including C. ceramicus, C. paniculatus and C. patens. As part of the continuing studies of C. paniculatus, we report herein the isolation and structural determination of one triterpenoid and two flavonoids from the stems and leaves of this species. Materials and method: The stems and leaves of C. paniculatus were collected from Vinh Linh district, Quang Tri province in August 2017. Compounds were islated by using various chromatographic methods. Their structures were determined by NMR spectroscopic method. Results and Conclusion: Dammara-20,24-dien-3b-ol (1), quercetin-3-O-α-L-rhamnopyranoside (2) and kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (3) were isolated and determined from the stems and leaves of C. paniculatus. Among these, compound 1 was isolated from the Chisocheton genus for the first time. Key words: Meliaceae, Chisocheton paniculatus, dammara-20,24-dien-3b-ol, quercetin-3-O-α-Lrhamnopyranoside, kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-d-glucopyranoside

Publisher

Hue University of Medicine and Pharmacy

Reference16 articles.

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3. Zhang F., He X. F., Wu W. B., Chen W. S., Yue J. M. (2012), New apotirucallane-type triterpenoids from Chisocheton paniculatus, Natural Products and Bioprospecting, 2: 235-239.

4. Nguyễn Thị Hoài, Hồ Việt Đức (2018), Thành phần hóa học cành và lá cây quếch Chisocheton paniculatus Hiern - Meliaceae, Tạp chí Dược học, 510: 85-88.

5. Nguyễn Thị Hoài, Lê Vĩnh Chương, Hà Thị Thuận, Vũ Thị Thu, Hồ Việt Đức (2018), Các terpenoid, steroid, và δ-tocopherol từ cành và lá cây quếch, Tạp chí Dược liệu, 23(6): 335-339.

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