ASSOCIATION OF C677T POLYMORPHISMS OF MTHFR GENE WITH RECURRENT PREGNANCY LOSS IN VIETNAMESE WOMAN-Reference-Cited by-同舟云学术

ASSOCIATION OF C677T POLYMORPHISMS OF MTHFR GENE WITH RECURRENT PREGNANCY LOSS IN VIETNAMESE WOMAN

Published:2019-02 Issue: Volume: Page:7-12
ISSN:1859-3836
Container-title:Journal of Medicine and Pharmacy
language:vi
Short-container-title:JMP

Author:

Le Thanh Nha Uyen¹,Ha Thi Minh Thi¹,Nguyen Viet Nhan¹

Affiliation:

1. Department of Medical Genetics, Hue University of Medicine and Pharmacy

Abstract

Background: Recurrent pregnancy loss is a major concern in gynecology. Recently, many papers have showed the role of genetic factors in etiology of recurrent pregnancy loss. Several published studied revealed that C677T polymorphism is a high risk of recurrent pregnancy loss. However, this finding is still controversy. Therefore, this study is aimed at investigating the association of C677T polymorphisms of MTHFR gene with recurrent pregnancy loss in Vietnamese woman. Methods: Study subjects comprised 100 healthy women (control group) and 52 women with recurrent pregnancy loss. C677T polymorphisms were identified by PCR-technique. Results: The frequency of 677CC, 677CT, and 677TT genotypes in Vietnamese women with recurrent pregnancy loss is 65.4%, 30.8%, 3.8%, respectively; while the distribution of those genotypes in the control-group is 86%, 12%, và 2% (χ2 = 8.83; p = 0.012). Statistic analysis revealed that MTHFR C677T polymorphismsare associated with recurrent pregnancy loss (for CT vs. CC: OR= 3.37, 95%CI: 1.44 – 7.87, p = 0.0049; for (677CT + 677TT) vs. CC: OR= 3.25, 95%CI: 1.46 – 7.26, p = 0.004; for T vs. C: OR= 2.74, 95%CI:1.55 – 5.55, p = 0.005). Key words: Recurrent pregnancy loss, C677T polymorphisms, MTHFR gene

Publisher

Hue University of Medicine and Pharmacy

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