SCREENING OF POTENTIAL INHIBITOR FOR FTSZ GTPASE ACTIVITY FROM PLANTS COLLECTED IN CENTRAL OF VIETNAM

Abstract

Background: FtsZ is conserved in almost all bacteria and is an essential protein for bacterial cell division. The cell division is prevented by the inhibitors against FtsZ’s functions. Thus, FtsZ is known as an attractive, and underexploited novel antibacterial target protein. The aim of this research is searching for new antibacterial agents from 72 plants collected in Central Vietnam. Materials and methods: The plant samples were collected in Central Vietnam. The extracts were tested for FtsZ inhibitory effect by FtsZ GTPase assay. Results and conclusions: Three samples displayed considerable FtsZ’s inhibitory activity among 72 extracts from the plants collected in Central of Vietnam. There are extracts of Annona glabria L., Grevillea robusta A. Cunn. Ex R. Br. and Sarcosperma affinis Gagnep inhibit FtsZ GTPase activity at 55.76 ± 4.20, 64.43 ± 5.55 and 88.36 ± 6.50 %, tested concentration 500 μg/mL, respectively. The results suggest that further researches should be conducted for discovery antibacterial chemical components. Key words: FtsZ’s inhibitory activity, antibacterial, Annona glabra, Grevillea robusta, Sarcosperma affinis