Comprehensive Review On Nanomicelles Drug Delivery System

Abstract

Many novel drug molecules in a clinical study as well as many existing drug molecules are lipophilic or hydrophobic in nature and thus they usually shows low bioavailability, poor absorption properties, low permeation as well as inability to reach at effective therapeutic concentration in blood. To overcome this problem, nanomicelles is the break through drug delivery system in which a lipophilic drug can be incorporated in polymeric micelles or surfactant micelles that can provide high solubility as well as high bioavailability. Due to the fact that Micelles have inner lipophilic core and outer hydrophilic shell as well as the inner lipophilic core provide space for incorporation for lipophilic drug, it enhances permeability of the lipophilic drug even at depth and also at target site. The present article provides overview of various applications of nanomicelles, it’s advantages as well as limitations, methods of preparations and various approaches for applications of nanomicelles.