Author:
liu dongliang,zhang hang,ma xiulan,dong yaodong
Abstract
Cholesteatoma of the middle ear is a common disease in otolaryngology that is receiving increasing attention. It is estimated that over 5 million people around the world are suffering from middle ear cholesteatoma. The yearly frequency of middle ear cholesteatoma is detailed as 9.2 per 100,000 in adults and 3 per 100,000 in children. Without timely discovery and intervention, cholesteatomas can become perilously large and attack intratemporal structures, coming about in various intra- and extracranial complications. So far, no practical nonsurgical treatments are available. Although multiple hypotheses exist, research directions are relatively consistent, focusing on cell proliferation, apoptosis, and bone destruction. Recently, non-coding RNA (ncRNA) especially miRNAs, lncRNAs, and circRNAs, have received increasing attention because of their key roles in gene expression, cell cycle regulation, and the development of many diseases. Although ncRNAs are not involved in protein translation, they are abundant in the genome, with only approximately 2% of genes encoding proteins and the remaining approximately 98% encoding ncRNA. The purpose of this review is to summarize the current state of knowledge regarding the specific role of ncRNA in middle ear cholesteatoma.
Publisher
Korean Society of Otorhinolaryngology-Head and Neck Surgery
Subject
Otorhinolaryngology,Surgery
Cited by
2 articles.
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