Chemotherapy in older adults with gastrointestinal cancer:Current practices and future directions in Japan

Author:

Sato Yasushi1,Okamoto Koichi2,Miyamoto Hiroshi2,Takayama Tetsuji2

Affiliation:

1. Department of Community Medicine for Gastroenterology and Oncology, Tokushima University Graduate School of Medical Science, Tokushima, Japan

2. Department of Gastroenterology and Oncology, Tokushima University Graduate School of Medical Science, Tokushima, Japan

Publisher

University of Tokushima Faculty of Medicine

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference25 articles.

1. 1. Japanese gastric cancer treatment guidelines 2021 6th edition. The Japanese Gastric Cancer Society 2021. 7. Kanehara & Co., Ltd

2. 2. Clinical practice guidelines of cancer drug therapies for the elderly. Japanese Society of Medical Oncology. Japan Society of Clinical Oncology 2019/7:Nankodo, Japan

3. 3. Hall PS, Swinson D, Cairns DA, Waters JS, Petty R, Allmark C, Ruddock S, Falk S, Wadsley J, Roy R, Tillett T, Nicoll J, Cummins S, Mano J, Grumett S, Stokes Z, Kamposioras KV, Chatterjee A, Garcia A, Waddell T, Guptal K, Maisey N, Khan M, Dent J, Lord S, Crossley A, Katona E, Marshall H, Grabsch HI, Velikova G, Ow PL, Handforth C, Howard H, Seymour MT;GO2 Trial Investigators:Efficacy of reduced-intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced gastroesophageal cancer:The GO2 Phase 3 Randomized Clinical Trial. JAMA Oncol 7:869, 2021

4. 4. Cunningham D, Lang I, Marcuello E, Lorusso V, Ocvirk J, Shin DB, Jonker D, Osborne S, Andre N, Waterkamp D, Saunders MP;AVEX study investigators:Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX):an open-label, randomised phase 3 trial. Lancet Oncol 14:1077-1085, 2013

5. 5. Winther SB, Liposits G, Skuladottir H, Hofsli E, Shah CH, Poulsen L?, Ryg J, Osterlund P, Berglund ?, Qvortrup C, Glimelius B, Sorbye H, Pfeiffer P:Reduced-dose combination chemotherapy (S-1 plus oxaliplatin) versus full-dose monotherapy (S-1) in older vulnerable patients with metastatic colorectal cancer (NORDIC9):a randomised, open-label phase 2 trial. Lancet Gastroenterol Hepatol 4:376-388, 2019

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