1. Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, Japan
2. These two authors equally contribute to this research.
3. Department of Digestive Surgery and Transplantation, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
4. Division of Colon and Rectal Surgery, Baylor University Medical Center, Dallas, TX, USA.