Author:
Farhood Abeer Hadi,Muttlaq Amena Lafeta,Khudair Teeba T.
Abstract
General Background: Escherichia coli is a widely distributed species that includes strains ranging from highly pathogenic to harmless avirulent isolates, often found in the human gut. Specific Background: E. coli pathogenicity is determined by virulence factors like adhesins, invasins, toxins, and capsules, which are often transferred horizontally via phages and plasmids. Knowledge Gap: Despite advancements in understanding E. coli virulence, there is a need to further understand genetic factors contributing to urinary tract infections, especially in regions with high antibiotic resistance. Aims: The study investigated the prevalence of virulence genes and antibiotic resistance in E. coli strains from UTI patients at Al Hussien Teaching Hospital in Iraq. Results: The study reveals the presence of specific virulence genes in UPEC strains from a specific region, suggesting the potential involvement of the pap AH gene in UTI pathogenesis. Novelty: This study reports the prevalence of specific virulence genes in UPEC strains from a specific region, indicating the potential role of the pap AH gene in UTI pathogenesis. Implications: The study indicates that UPEC strains, characterized by high virulence factors like pap AH, are promising vaccine targets, necessitating further research for effective prevention strategies.
Highlights:
E. coli strains show high antibiotic resistance in UTI patients.
pap AH gene is crucial for UPEC virulence.
Virulence factors like pap AH are potential vaccine targets.
Keywords: E. coli, UTI, virulence factors, antibiotic resistance, pap AH gene
Publisher
Universitas Muhammadiyah Sidoarjo
Reference33 articles.
1. . D. Tambekar, D. Dhanorkar, S. Gulhane, V. Khandelwal, and M. Dudhane, “Antibacterial Susceptibility of Some Urinary Tract Pathogens to Commonly Used Antibiotics,” African Journal of Biotechnology, 2006. [Online]. Available: https://www.ajol.info/index.php/ajb/article/view/43162
2. . H. Garrec, L. Drieux-Rouzet, J.-L. Golmard, V. Jarlier, and J. Robert, “Comparison of Nine Phenotypic Methods for Detection of Extended-Spectrum β-Lactamase Production by Enterobacteriaceae,” Journal of Clinical Microbiology, vol. 49, no. 3, pp. 1048–1057, Mar. 2011, doi: 10.1128/jcm.02130-10.
3. . K. Naber, “Improved Classification of Urinary Tract Infection: Future Considerations,” Academia.edu, Mar. 2024. [Online]. Available: https://www.academia.edu/115819659/Improved_Classification_of_Urinary_Tract_Infection_Future_Considerations
4. . M. M. Zacchè and I. Giarenis, “Therapies in Early Development for the Treatment of Urinary Tract Inflammation,” Expert Opinion on Investigational Drugs, vol. 25, no. 5, pp. 531–540, Mar. 2016, doi: 10.1517/13543784.2016.1161024.
5. . R. Kucheria, P. Dasgupta, S. H. Sacks, M. S. Khan, and N. S. Sheerin, “Urinary Tract Infections: New Insights into a Common Problem,” Postgraduate Medical Journal, vol. 81, no. 952, pp. 83–86, Feb. 2005, doi: 10.1136/pgmj.2004.023036.