Author:
Muslim Ibrahim H.,Neamah Nadheerah F.,Shari Falah H.
Abstract
Sodium copper chlorophyllin (SC-C) is widely used for its biological properties and color. This study evaluated SC-C's antioxidative and anti-inflammatory effects in male rats treated with indomethacin. Fifty rats were divided into five groups: control, indomethacin, rabeprazole, and two SC-C dosages (35 mg/kg and 70 mg/kg). Indomethacin reduced serum GPx levels, but rabeprazole and SC-C treatments restored them. MDA levels increased with indomethacin but normalized with other treatments. Indomethacin also lowered IL-10, IL-4, and TNF, which returned to normal in treated groups. Histopathology showed SC-C reversed liver damage from indomethacin. SC-C demonstrates strong antioxidant and anti-inflammatory activities, suggesting its potential as a therapeutic agent.
Highlight:
SC-C significantly restores serum GPx levels reduced by indomethacin.
SC-C normalizes MDA, IL-10, IL-4, and TNF levels, countering oxidative stress.
Histopathology shows SC-C reverses liver damage induced by indomethacin.
Key wards: Sodium copper chlorophyllin, antioxidant, anti-inflammatory, indomethacin, oxidative stress
Publisher
Universitas Muhammadiyah Sidoarjo
Reference20 articles.
1. Carlini, V., Noonan, D. M., Abdalalem, E., Goletti, D., Sansone, C., Calabrone, L., & Albini, A. (2023). The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions. Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1161067
2. Ciciliato, M. P., de Souza, M. C., Tarran, C. M., de Castilho, A. L. T., Vieira, A. J., & Rozza, A. L. (2022). Anti-Inflammatory Effect of Vanillin Protects the Stomach against Ulcer Formation. Pharmaceutics, 14(4). doi: 10.3390/pharmaceutics14040755
3. Ibtihal J. Naoor, N. F. N. a. J. K. H. (2023). A study of the protective effect of 5 Thiocyanatouracil against paracetamol overdose in rats History of Medicine, 9(2), 1-9. doi: https://doi.org/10.17720/2409-5834.v9.2.2023.001
4. Lanfer-Marquez, U. M., Barros, R. M. C., & Sinnecker, P. (2005). Antioxidant activity of chlorophylls and their derivatives. Food Research International, 38(8), 885-891. doi: https://doi.org/10.1016/j.foodres.2005.02.012
5. Lee, S. W., Hong, Y. S., Chun, C. M., Moon, J. D., Kim, S. J., Jung, I. C., . . . Moon, C. K. (2002). Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes. J Korean Med Sci, 17(1), 7-14. doi: 10.3346/jkms.2002.17.1.7