Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure-Reference-Cited by-同舟云学术

Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure

Published:2021-12-30 Issue:4 Volume: Page:48-56
ISSN:2412-5547
Container-title:Health of Man
language:
Short-container-title:HM

Author:

Shebeko Serhii¹^ORCID,Chernykh Vladyslava¹,Zupanets Kateryna¹^ORCID

Affiliation:

1. National University of Pharmacy, Ukraine

Abstract

This research aims at studying the nephroprotective properties of BNO 2103 in a model of chromate-induced renal failure in rats and at proving the possibility of using BNO 2103 in clinical practice for the complex treatment of chronic kidney disease (CKD). Materials and methods. Fifty rats divided into five groups were studied. The drugs BNO 2103, Prednisolone and Lespephril were administered within 20 days. The excretory function and the functional state of kidneys, blood biochemical parameters and indicators of nitrogen metabolism were determined. Results. Under the influence of BNO 2103, there was a significant improvement in renal excretory function, in nitrogen metabolism and blood biochemical parameters compared with the control pathology group. BNO 2103 also outperformed the comparators in most indicators. Conclusions. BNO 2103 has demonstrated nephroprotective, hypoazotemic and diuretic effects; and can be used to implement to the combined therapy of CKD.

Publisher

Professional Event, LLC

Subject

General Earth and Planetary Sciences,Water Science and Technology,Geography, Planning and Development

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