Dextran sulfate triggers platelet aggregation via direct activation of PEAR1
Author:
Affiliation:
1. Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
2. Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK
Publisher
Informa UK Limited
Subject
Hematology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.3109/09537104.2015.1111321
Reference12 articles.
1. Platelet Endothelial Aggregation Receptor 1 (PEAR1), a Novel Epidermal Growth Factor Repeat-containing Transmembrane Receptor, Participates in Platelet Contact-induced Activation
2. Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis
3. A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1
4. Sun Y, Vandenbriele C, Kauskot A, Verhamme P, Hoylaerts MF, Wright GJ. A human platelet receptor protein microarray identifies FcepsilonR1alpha as an activating PEAR1 ligand. Mol Cell Proteomics 2015;14(5):1265–1274.
5. Dextran sulphate induces fibrinogen receptor activation through a novel Syk-independent PI-3 kinase-mediated tyrosine kinase pathway in platelets
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