1. Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, Japan
2. Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
3. Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan 4Department of Clinical Reserch, Fukuoka National Hospital, Fukuoka, Japan