Affiliation:
1. Wil Research Laboratories, Inc. 1407 Montgomery Township Road 805 Ashland, OH 44805
Abstract
The potential involvement of sulfite, an obligatory intermediate in the metabolism of carbon disulfide (CS2) to sulfate, in CS2-induced hepatotoxicity in phenobarbital-pretreated rats was investigated. The activity of mitochondrial sulfite oxidase, which is the primary route for the oxidation of sulfite to sulfate, was decreased 78% by a regimen consisting of a low molybdenum diet and drinking water supplemented with tungstate. These rats also had 30% less cytochrome P-450 than those maintained on the control regimen. The dietary regimen did not enhance CS2-induced toxicity but, rather, provided some degree of protection, which was probably due to the decreased amount of cytochrome P-450. Hence, sulfite does not appear to be involved in CS2-induced hepatotoxicity in the rat.
Cited by
2 articles.
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1. Carbon disulfide [MAK Value Documentation, 1999];The MAK-Collection for Occupational Health and Safety;2012-01-31
2. Schwefelkohlenstoff (Kohlendisulfid) [MAK Value Documentation in German language, 1997];The MAK-Collection for Occupational Health and Safety;2012-01-31