Cloning of Genes Encoding Scorpion Toxins: An Interpretative Review

Author:

Becerril Baltazar,Corona Miguel,García Consuelo,Bolívar Francisco,Possani Lourival D.

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference57 articles.

1. Purification of Animal Neurotoxins. Isolation and Characterization of Eleven Neurotoxins from the Venoms of the Scorpions Androctonus australis Hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus

2. Zlotkin E., Miranda F., Rochat C. Handbook of Experimental Pharmacology: Chemistry and pharmacology of Buthinae scorpion venoms, S. Bettini. Springer-Verlag, Berlin 1978; 317

3. Possani L. D. Handbook of Natural Toxins, A. T. Tu. Marcel Dekker Inc, New York 1984; 513, The contribution of Brazilian scientists on this subject can be seen in reviews by: Diniz, C. R., in Arthropod venoms, edited by S. Bettini, p. 379, Springer-Verlag, Berlin, 1978 and Freire-Maia, L. and Campos, J. A., in Natural toxins, edited by C. L. Ownby and G. B. Odell, p. 139, Oxford: Pergamon Press, 1989. Among other additional informations are: Toledo, D. and Neves, A. G. A., Purification and partial characterization of a second toxin from the scorpion Tityus serrulatus, Comp. Biochem. Physiol., 55B:249, 1976; Machado, J. C. and Silveira F., J. F., Obtenção experimental da pancreatite hemorrágica aguda no cão por veneno escorpiônico, Mem. Inst. Butantan, 40/41:1, 1976/77; Novaˇes, G., Catanzaro, D. L., Beraldo, W. T. and Freire-Maia, L., Effect of purified scorpion toxin (tityustoxin) on the pancreatic secretion of the rat, Toxicon 20:847, 1982; Sampaio, S. V., Laure, C. J. and Giglio, J. R., Isolation and characterization of toxic proteins from the venom of the Brazilian scorpion Tityus serrulatus, Toxicon 21:265, 1983; Marangoni, S., Ghiso, J., Sampaio, S. V., Arantes, E. C., Giglio, J. R., Oliveira, B. and Frangione, B., The complete amino acid sequence of toxin TsTX-VI isolated from the venom of the scorpion Tityus serrulatus, J. Prot. Chem., 9:595, 1990

4. Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model

5. Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel

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