Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase-Reference-Cited by-同舟云学术

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

Published:2010-06-14 Issue:2 Volume:26 Page:169-175
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Mulchande Jalmira¹,Simões Sandra I.²,Gaspar Maria M.²,Eleutério Carla V.²,Oliveira Rudi¹,Cruz Maria E.M.²,Moreira Rui¹,Iley Jim³

Affiliation:

1. Medicinal Chemistry, iMed.UL, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, Lisbon, Portugal

2. Nanomedicine & Drug Delivery Systems, iMed.UL, Faculty of Pharmacy, University of Lisbon, Campus of Lumiar, Building F, R/C, Estrada do Paço do Lumiar, Lisbon, Portugal

3. Department of Chemistry and Analytical Sciences, 4The Open University, Milton Keynes, UK

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.3109/14756366.2010.486794

Reference32 articles.

1. Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

2. Chronic Obstructive Pulmonary Disease: A Growing but Neglected Global Epidemic

3. Neutrophil Elastase: Mediator of Extracellular Matrix Destruction and Accumulation

4. Leukocyte Elastase

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action;Bioorganic Chemistry;2023-09

2. Polysulfone Membranes Doped with Human Neutrophil Elastase Inhibitors: Assessment of Bioactivity and Biocompatibility;Membranes;2023-01-10

3. Discovery of New 3,3-Diethylazetidine-2,4-dione Based Thiazoles as Nanomolar Human Neutrophil Elastase Inhibitors with Broad-Spectrum Antiproliferative Activity;International Journal of Molecular Sciences;2022-07-08

4. Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management;Pharmaceutics;2020-04-14

5. Neutrophil Elastase Inhibitors and Chronic Kidney Disease;International Journal of Biological Sciences;2018