Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol-Reference-Cited by-同舟云学术

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Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol

Published:1996-01 Issue:6 Volume:26 Page:647-666
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Bessems J. G. M.,Te Koppele J. M.,Van Dijk P. A.,Van Stee L. L. P.,Commandeur J. N. M.,Vermeulen N. P. E.

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.3109/00498259609046740

Reference40 articles.

1. The effect of fluorine substitution on the hepatotoxicity and metabolism of paracetamol in the mouse

2. The Effect of Fluorine Substitution on the Physicochemical Properties and the Analgesic Activity of Paracetamol

3. 3,5-Disubstituted analogues of paracetamol. Synthesis, analgesic activity and cytotoxicity

4. Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinoneimine

5. Determinants of protein modification versus heme alkylation: inactivation of cytochrome P450 1A1 by 1-ethynylpyrene and phenylacetylene

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