Seminal Cytology and Reproductive Toxicology of N-Chloropiperidine

Abstract

Induction of sperm abnormality in mice and hamster and reproductive toxicity in mice was examined following chronic exposures (ad libitum) to N-chloropiperidine (NCP). The results showed that significant levels of abnormal sperm in the NCP treated group were observed after five weeks of exposure. The time of the appearance of NCP-induced anomalous sperm suggested that the compound did not affect late spermatocytes and spermiogenesis. Reproductive toxicological analysis based on moles, implantations, and offspring per pregnancy revealed that while the toxic effect of ethylmethane sulfonate was evident within the first week of treatment, NCP-induced toxicity was observed only after five weeks of treatment. The data further showed that in matings where both parents were exposed to NCP, the frequencies of moles, implantations, and offspring per pregnancy were fewer than those observed in single parent exposure.