Proposed Supplemental Dosages of Selenium for a Phase I Trial Based on Dietary and Supplemental Selenium Intakes and Episodes of Chronic Selenosis-Reference-Cited by-同舟云学术

Proposed Supplemental Dosages of Selenium for a Phase I Trial Based on Dietary and Supplemental Selenium Intakes and Episodes of Chronic Selenosis

Published:1986-01 Issue:1 Volume:5 Page:71-78
ISSN:0730-0913
Container-title:Journal of the American College of Toxicology
language:en
Short-container-title:Journal of the American College of Toxicology

Author:

Chen J.¹,Clark L.C.²

Affiliation:

1. Department of Preventive Medicine Cornell University Ithaca, NY 14853

2. Institute of Health, China National Center for Preventive Medicine, Beijing, People's Republic of China.

Abstract

Phase I trials are needed to identify the maximum safe dose of both inorganic and organic selenium (Se) compounds that could be used under medical supervision for patients at extremely high risk of cancer. Based on naturally occurring episodes of chronic selenosis and experience with Se supplementation trials, we recommend a range of doses for inorganic and organic Se compounds that should be investigated in a Phase I trial in order to identify the maximum tolerated dose for these compounds.

Publisher

SAGE Publications

Subject

Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.3109/10915818609140737

Reference14 articles.

1. ASSOCIATION BETWEEN SERUM SELENIUM AND THE RISK OF CANCER

2. PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCER

3. Selenium Compounds and the Prevention of Cancer: Research Needs and Public Health Implications

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