A Survey of Metal-induced Mutagenicity in Vitro and in Vivo

Abstract

A survey of the literature shows that organic and inorganic compounds of 53 metals have been assayed for genotoxic effects in vitro and in vivo. It is found that there are great variations in the response obtained with different test systems and that a wide range of compounds of the different metals is positive in at least one of the short-term tests. Some of the variation observed could be due to differences in uptake mechanisms. This effect plus the wide variation in the quantity and quality of the data prevents any direct comparison of in vitro activity with in vivo potency of the various metallic species.