Evaluation of Sensory System Function Using Reflex Modification of the Startle Response

Abstract

Methods to measure damage to sensory systems after toxicant exposure vary from rapid and subjective tests (e.g., pinna reflex) to time-consuming and objective tests (e.g., psychophysical tests). Reflex modification of the startle response represents an alternative technique in the assessment of sensory function. Advantages of this procedure include no prior training requirements, rapid and objective measurement of sensory thresholds, ability to differentiate sensory from nonsensory damage, and potential for predictive validity. This procedure also has been shown to be sensitive to a variety of neurotoxic compounds. Future research should concentrate on demonstrating the research potential of this technique for use in neurotoxicology.