The Mechanism of a P-450 Enzyme-Aromatase; a Molecular Modelling Perspective for the Removal of the C(19) Methyl and Aromatisation of the Steroid a Ring
Author:
Publisher
Informa UK Limited
Subject
Molecular Medicine,Biochemistry
Link
http://www.tandfonline.com/doi/pdf/10.3109/14756369709027664
Reference15 articles.
1. Aromatase inhibitors and their potential clinical significance
2. The stereospecific removal of a C-19 hydrogen atom in oestrogen biosynthesis
3. The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization
4. Mechanistic consideration of P-450 dependent enzymic reactions: studies on oestriol biosynthesis
5. Mechanism and inhibition of cytochrome P-450 aromatase
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1. Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-Hydroxylase/17,20-Lyase (P45017α);The Journal of Steroid Biochemistry and Molecular Biology;2008-05
2. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α);Bioorganic & Medicinal Chemistry Letters;2006-09
3. Lead Reduces Messenger RNA and Protein Levels of Cytochrome P450 Aromatase and Estrogen Receptor β in Human Ovarian Granulosa Cells1;Biology of Reproduction;2003-06-01
4. Nonsteroidal aromatase inhibitors: Recent advances;Medicinal Research Reviews;2002-03-26
5. Study of substrate specificity of human aromatase by site directed mutagenesis;European Journal of Biochemistry;2002-03-01
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