Thrombin Inhibitors as Antithrombotic Agents: The Importance of Rapid Inhibition
Author:
Publisher
Informa UK Limited
Subject
Molecular Medicine,Biochemistry
Link
http://www.tandfonline.com/doi/pdf/10.3109/14756369509040677
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4. A player of many parts: The spotlight falls on thrombin's structure
5. The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
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1. Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug;Bioorganic & Medicinal Chemistry Letters;2013-09
2. Beyond Heparinization: Design of Highly Potent Thrombin Inhibitors Suitable for Surface Coupling;ChemMedChem;2012-08-20
3. Small bite, large impact–saliva and salivary molecules in the medicinal leech, Hirudo medicinalis;Naturwissenschaften;2011-11-09
4. Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors;PLoS ONE;2011-10-28
5. Immobilization of the irreversible thrombin inhibitor D-Phe-Pro-Arg-chloromethylketone: A concept for hemocompatible surfaces?;Journal of Biomedical Materials Research Part A;2010
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