A Multicentre Double Blind Trial of Fluoxetine versus Amitriptyline in the Treatment of Depressive Illness-Reference-Cited by-同舟云学术

A Multicentre Double Blind Trial of Fluoxetine versus Amitriptyline in the Treatment of Depressive Illness

Published:1993-03 Issue:1 Volume:27 Page:49-55
ISSN:0004-8674
Container-title:Australian & New Zealand Journal of Psychiatry
language:en
Short-container-title:Aust N Z J Psychiatry

Author:

Judd Fiona K.¹,Moore Kate¹,Norman Trevor R.¹,Burrows Graham D.¹,Gupta Ramesh K.²,Parker Gordon³

Affiliation:

1. University of Melbourne, Department of Psychiatry, Austin Hospital, Heidelberg, Victoria

2. Royal Canberra Hospital, Garran, ACT

3. School of Psychiatry, University of New South Wales, Prince of Wales Hospital, Randwick, New South Wales

Abstract

The antidepressant efficacy and side effect profile of a fixed dose of 20 mg/day of fluoxetine, a specific serotonin reuptake inhibitor, were compared to those of amitriptyline. Fifty-eight patients with DSM-III-R depression were randomly assigned to receive either fluoxetine or amitriptyline. Fifty-six patients (fluoxetine N = 23, amitriptyline N = 23) completed the 6 week study. Comparable antidepressant efficacy was demonstrated for the two drugs. Patients taking fluoxetine reported less side-effects than those taking amitriptyline.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.3109/00048679309072123

Reference26 articles.

1. Use of Specific Serotonin Uptake Inhibitors as Antidepressants

2. Fluoxetine, a Highly Selective Serotonin Reuptake Inhibitor: A Review of Preclinical Studies

3. Fluoxetine: Efficacy Against Placebo and by Dose-An Overview

4. A Comparative Trial of a New Antidepressant, Fluoxetine

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