Clozapine: A Mimicry of Phaeochromocytoma

Author:

Li June K.Y.1,Yeung Vincent T.F.1,Leung C. M.1,Chow C. C.1,Ko Gary T.C.1,So W. Y.1,Cockram C. S.1

Affiliation:

1. Department of Medicine and Therapeutics and Department of Psychiatry, Prince of Wales Hospital, Shatin, New Territories, Hong Kong

Abstract

Objective: To report a case of clozapine-induced hypertension with raised urinary catecholamines. Clinical picture: A 27–year-old man fulfilling DSM-Ill-R criteria for catatonic schizophrenia was treated with clozapine. He later developed both hypertension and raised urinary catecholamines which mimicked phaeochromocytoma. Treatment: Clozapine was withdrawn. Outcome: Both blood pressure and urinary catecholamines normalised. Conclusions: Clozapine may induce sympathetic hyperactivity.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,General Medicine

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1. Schizophrenia and Related Psychoses;The Maudsley Prescribing Guidelines in Psychiatry;2021-12-02

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