A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice-Reference-Cited by-同舟云学术

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice

Published:2015-03-24 Issue:3 Volume:25 Page:229-233
ISSN:1537-6516
Container-title:Toxicology Mechanisms and Methods
language:en
Short-container-title:Toxicology Mechanisms and Methods

Author:

Kassa Jiri,Sepsova Vendula,Matouskova Lenka,Horova Anna,Musilek Kamil

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://www.tandfonline.com/doi/pdf/10.3109/15376516.2015.1036333

Reference32 articles.

1. Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment

2. Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice

3. Organophosphorus compounds as chemical warfare agents: a review

4. A new and rapid colorimetric determination of acetylcholinesterase activity

5. Structure-Activity Relationship and Efficacy of Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds: A Review of Recent Data

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1. Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators;Toxicology and Applied Pharmacology;2019-11

2. Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models;Chemico-Biological Interactions;2019-09

3. The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats;BMC Pharmacology and Toxicology;2018-06-28

4. In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication;Toxicology Mechanisms and Methods;2017-08-04

5. HI-6 TREATMENT DOES NOT REACTIVATE SARIN INHIBITED ACETYLCHOLINESTERASE ACTIVITY IN DOG BRAIN WHEN ADMINISTERED IN HUMAN THERAPEUTICAL DOSE 30 MINUTES AFTER THE POISONING;Military Medical Science Letters;2016-03-04