Human polymerase α inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives

Author:

Höltje Monika1,Richartz Anja2,Zdrazil Barbara1,Schwanke Anja2,Dugovic Branislav3,Murruzzu Caterina3,Reißig Hans-Ulrich3,Korting Hans Christian4,Kleuser Burkhard2,Höltje Hans-Dieter1,Schäfer-Korting Monika2

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie, Heinrich Heine-Universität Düsseldorf, Germany

2. Institut für Pharmazie (Pharmakologie und Toxikologie) der Freien Universität Berlin, Berlin, Germany

3. Institut für Chemie und Biochemie (Organische Chemie) der Freien Universität Berlin, Berlin, Germany

4. Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität, München, Germany

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Base-Modified Nucleosides as Chemotherapeutic Agents: Past and Future;Current Topics in Medicinal Chemistry;2016-03-03

2. Core-Shell Nanotransporters for the Skin;Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement;2016

3. Cationic membrane-active peptides - anticancer and antifungal activity as well as penetration into human skin;Experimental Dermatology;2014-04-28

4. DNA Dependent DNA Polymerases as Targets for Low-Weight Molecular Inhibitors: State of Art and Prospects of Rational Design;Challenges and Advances in Computational Chemistry and Physics;2014

5. Molecular modelling studies of new potential human DNA polymerase α inhibitors;Journal of Enzyme Inhibition and Medicinal Chemistry;2010-10-20

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