Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences-Reference-Cited by-同舟云学术

Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences

Published:2010-01-25 Issue:5 Volume:25 Page:679-684
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Lewis David FV¹,Ito Yuko²,Lake Brian G³

Affiliation:

1. Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK

2. Graduate School of Integrated Science, Division of Science of Biological, Supramolecular Systems, Structural Bioinformatics, Yokohama City University, 1-7-29, Suehirocho, Tsurumi-Ku, Yokohama, Kanagawa, 230-0045, Japan

3. Centre for Toxicology, Faculty of Health, and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.3109/14756360903514149

Reference28 articles.

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2. Lewis DFV. Guide to Cytochromes P450 Structure and Function. London:Taylor & Francis, 2001:76–117.

3. Nims RW, Lubet RA. The CYP2B subfamily. In: C Ioannides, ed. Cytochromes P450 - Metabolic and Toxicological Aspects. Boca Raton, Fl: CRC Press, 1996:135–160.

4. The Functional Role of CYP2B6 in Human Drug Metabolism: Substrates and Inhibitors In Vitro, In Vivo and In Silico

5. Structural Basis of Selective Cytochrome P450 Inhibition

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