Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity

Author:

Tripathi Ashutosh1,Durrant David2,Lee Ray M.2,Baruchello Riccardo3,Romagnoli Romeo3,Simoni Daniele3,Kellogg Glen E.1

Affiliation:

1. Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA, USA

2. Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA

3. Dipartimento di Scienze, Farmaceutiche, Universitá di Ferrara, Ferrara, Italy

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference19 articles.

1. World Health Organization. Fact Sheet (Cancer) No. 297 Available at http://www.who.int/mediacentre/factsheets/fs297/en/index.html.

2. American Cancer Society. Global Cancer Facts and Figures 2007. Available at http://www.cancer.org

3. Medicinal Chemistry of Combretastatin A4:  Present and Future Directions

4. Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin

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