Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosisin vitroand in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways-Reference-Cited by-同舟云学术

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Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosisin vitroand in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways

Published:2013-08-20 Issue:3 Volume:55 Page:668-676
ISSN:1042-8194
Container-title:Leukemia & Lymphoma
language:en
Short-container-title:Leukemia & Lymphoma

Author:

Wu Kang-Ni,Zhao Yan-Min,He Ying,Wang Bin-Sheng,Du Kai-Li,Fu Shan,Hu Kai-Min,Zhang Li-Fei,Liu Li-Zhen,Hu Yong-Xian,Wang Ying-Jia,Huang He

Publisher

Informa UK Limited

Subject

Cancer Research,Oncology,Hematology

Link

http://www.tandfonline.com/doi/pdf/10.3109/10428194.2013.811579

Reference36 articles.

1. The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

2. NOTCH and PI3K-AKT Pathways Intertwined

3. Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis

4. Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition

5. Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors

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1. Biology and Therapeutic Properties of Mesenchymal Stem Cells in Leukemia;International Journal of Molecular Sciences;2024-02-21

2. Rigosertib is more potent than wortmannin and rapamycin against adult T‐cell leukemia‐lymphoma;BioFactors;2023-06-22

3. In vitro simulation of the acute lymphoblastic leukemia niche: a critical view on the optimal approximation for drug testing;Journal of Leukocyte Biology;2023-04-11

4. Anti-leukemic effect and molecular mechanism of 11-methoxytabersonine from Melodinus cochinchinensis via network pharmacology, ROS-mediated mitochondrial dysfunction and PI3K/Akt signaling pathway;Bioorganic Chemistry;2022-03

5. Growth inhibition and suppression of the mTOR and Wnt/β‐catenin pathways in T‐acute lymphoblastic leukemia by rapamycin and MYCN depletion;Hematological Oncology;2020-12-23

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