Abstract
Background: Caring for children with thalassemia under stressful conditions adversely affects the health of mothers. Objectives: This study aims to explore factors causing anxiety and coping strategies among these mothers during the COVID-19 pandemic. Methods: This cross-sectional study utilized convenience sampling and included three questionnaires: The Coronavirus Disease Anxiety Scale (CDAS), the Carver Coping Strategies Questionnaire, and a Demographic Information Questionnaire. The questionnaires were filled out in person. Considering the study variables and allocating 15 samples per variable, the sample size was determined to be 200 participants. Results: The results indicated no significant difference in average anxiety levels between mothers with underlying diseases and those without. The multiple regression analysis (F = 13.950, AR2 = 0.163, P < 0.01) confirmed the model's significance. Problem-oriented, emotion-oriented, and avoidance-oriented coping styles significantly impacted anxiety (P < 0.01). Conclusions: It is recommended to promote problem-oriented coping strategies during the COVID-19 pandemic to reduce anxiety among these mothers.