Interactive Effect of Grape Seed Nanoparticle Extract and Resistance Training on Antioxidant System Function in Myocardial Infarction Rat Model

Abstract

Background: The use of herbal supplements and exercise to treat chronic diseases and metabolic disorders is a common practice. Objectives: This study aimed to investigate the effect of eight weeks of grape seed nanoparticle extract and resistance training on SOD, MDA, and NRF-1 expression in the myocardial infarction rat model. Methods: In this experimental trial, 25 Wistar rats were randomly divided into five groups: (1) control, (2) MI, (3) RT + MI, (4) GS + MI, and (5) RT + MI + GS. Resistance training was performed for eight weeks and five sessions per week. Also, 150 mg of grape seed extract was gavage daily. One-way analysis of variance and the Tukey test was used to compare groups at the P ≤ 0.05. Results: Resistance training with grape seed significantly increased NRF-1 gene expression (P = 0.001) and SOD (P = 0.01) compared to MI grope. While resistance training with grape seed significantly reduced MDA compared to the MI group (P = 0.01). Conclusions: It seems that resistance training with grape seed consumption has a more positive effect on increasing NRF-1 gene expression and improving the antioxidant system in the heart tissues of rats with myocardial infarction rather than using each alone.