Effects of Toxoplasma gondii on Sperm Parameters and Histomorphometry of Testis in Experimentally Infected Rats

Abstract

Background: Toxoplasma gondii, an obligate intracellular parasite, can be involved in the infection of the male reproductive system. Objectives: Since more than a third of the human population and an increasing number of couples with idiopathic infertility are affected by toxoplasmosis, there is a necessity to evaluate the effects of T. gondii on the reproductive system. Methods: In this experimental study, detailed description of sperm parameters, hormone levels (testosterone, follicular stimulating factor [FSH], and luteinizing hormone [LH]), and histomorphometric analysis were gathered every 10 days on T. gondii infected Wistar male rats until day 80. Data on testis and body weight were also collected. Results: Sperm parameters (motility, viability, count, and normal sperms) as well as LH level were significantly lower in infected rats. No significant decrease was observed in FSH and testosterone levels. The number of Leydig cells significantly decreased on day 20. Significant reduction of Sertoli cells was also detected on day 60. Bodyweight reduced significantly on days 20 and 60, but the testis weight was elevated. Conclusions: T. gondii infection can lead to diminished fertility parameters, but not sterility in rats. The parasite could temporarily interfere with the male reproductive system.