Comparative study of GA and MAC Anesthesia Methods Effects on Oocyte Retrieval in Patients Under IVF Programs

Abstract

Background: Anesthesia is widely used to manage pain and anxiety during oocyte retrieval in vitro fertilization (IVF), but there is probable interference with the results and success rate of IVF. Objectives: The present study compares the effects of general anesthesia (GA) and monitored anesthesia care (MAC) applied in oocyte retrieval. Methods: The general anesthesia used in this study comprised a fentanyl-propofol mixture to reach hypnotic concentrations. Intravenous ketamine-midazolam were used for MAC before procedures according to prescribed doses. In sum, 180 women were recruited for research while 90 women selected for general and 90 for MAC methods. Results: The collected oocytes were higher in number in general group (11.25 ± 4.39) than MAC group (7.03 ± 3.84, P < 0.001), meanwhile, the analyses did not show difference between groups regarding the number of fertilized oocytes (4.52 ± 3.18 vs. 4.15 ± 3.02). The differences in successful pregnancy was not significant. Conclusions: Thus, it seems from findings that fentanyl-propofol GA without nitrous oxide is an appropriate alternative to ketamine-midazolam MAC and can be used for IVF oocyte retrieval if GA is demanded.