Abstract
: Angiotensin-converting enzyme 2 (ACE2) is widely known as the essential receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is the cause of the globally known coronavirus disease 2019 (COVID-19) pandemic, which has been the leading cause of virus-related mortality since early 2020. A wide range of human cells in different human organs express ACE2. The importance of ACE2 in the involvement of human organs during COVID-19 and its critical role in the process of target cell infection have rendered it an interesting therapeutic target. In this review, we briefly focus on ACE2 and its general roles in the human body and highlight the roles of ACE2 in the emergence of COVID19. Ultimately, we discuss the strategies for preventing virus entry using ACE2 blocking.