World Experience in the Use Serogroup B Meningococcal Vaccines (literature review)

Author:

Koroleva I. S.1ORCID,Koroleva M. A.1ORCID

Affiliation:

1. Central Research Institute of Epidemiology of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance

Abstract

Relevance. The success of vaccine prophylaxis of meningococcal infection depends on the composition and properties of vaccine preparations and the strict implementation of recommendations on vaccine prophylaxis tactics by the territorial epidemiological characteristics of meningococcal infection. Despite the high burden of B-meningococcal infection, especially among young children, the design of B-meningococcal vaccines has faced serious difficulties. Aim. The literature review presents the history of the development of B-meningococcal vaccines and provides characteristics of two immunologically effective and safe new generation B-meningococcal vaccine preparations. Conclusion. The licensing of the two new B-meningococcal vaccines presented in the review (Bexsero and Trumenba) was based on immunogenicity and safety. The inclusion of vaccines in national vaccination programs requires careful analysis, including analysis of the antigenic characteristics of circulating strains.

Publisher

LLC Numicom

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,Epidemiology

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