Affiliation:
1. Khabarovsk scientific-research institute of epidemiology and microbiology of Rospotrebnadzor
2. Pacific state medical university of Ministry of Healthcare of the Russian Federation
Abstract
Relevance. Monitoring the genotypic diversity of the hepatitis C virus as well as its prevalence in the population, including in certain population groups, is an important public health task.Aim. To analyze main epidemiological indices (incidence and prevalence) among people living with HIV and evaluate abundance of chronic hepatitis C among them, reveal molecular-genetic distribution of hepatitis C virus (HCV) isolated from HIV-positive people living in the Far Eastern Federal district (FEFD) of the Russian Federation.Materials and methods: a retrospective epidemiological analysis including estimation of HIV-infection incidence and prevalence as well as percent of HIV-positive people suffering from chronic viral hepatitis C was conducted for nine constituent entities of the FEFD. Molecular genetic analysis included evaluation of 120 samples of serum positive for HCV RNA that was obtained from people diagnosed with HIV-infection. A type-specific commercial PCR test-kit as well as partial sequencing by Sanger of HCV NS5B gene (241 bp and 350 bp) were utilized in order to specify HCV genotypes.Results and discussion: in total 26.26% of people living with HIV were registered for regular medical examination due to chronic hepatitis C in the FEFD in year 2019. Their percentage has grown over a 5-year period. Dominant HCV subtype among surveyed HIV-positive people was subtype 3a followed by HCV subtype 1b. HCV genotype 2 and subtype 1a were detected less frequently and were identified as minor genotypes. Genotype distribution among people aged under 35 years was more significant in comparison with older citizens. Some regional particularities were discovered. For example, HCV genotype 2 was registered more frequently in the Khabarovsk krai compared to mean estimated value of the sampling collection. Subtype 1b was dominant in Republic Sakha (Yakutia).Conclusion: an increase in percent of HIVinfected people suffering from chronic hepatitis C has been noted during a 5-year period. Should be noted that the value varies in different constituent entities ofthe FEFD. Molecular-genetic analysis showed general prevalence of HCV 3a subtype while 1b HCV subtype is dominant in the Russian Federation in patients suffering from HCV-monoinfection as well as in those infected with HIV and HCV.
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health,Epidemiology
Reference31 articles.
1. Kuznetsova A.V., Vitko A.V., Karavyanskaya T.N., Baglai I.A., Rogachikova A.E., Vorontsova G.A., Rud S.S. Parenteral viral hepatitis in the Russian Far East: virological and epidemiological peculiarities in monoinfected patients and those co-infected with HIV. Clinical pharmacology and therapy. 2015;24(1):34–37 (In Russ.).
2. Medvedeva T.V., Nekipelov O.M., Nikitina E.G., Skvortsova R.G. Оn necessity of obligatory research of samples, positive to hepatitis С, for HIV presence. Siberian medical journal. 2010;(6):187–188 (In Russ.).
3. Welzel T.M., Bhardwaj N., Hedskog C., Chodavarapu K., Camus G., McNally J., Agarwal K. Global epidemiology of HCV subtypes and resistance-associated substitutions evaluated by sequencing-based subtype analyses. Journal of Hepatology. 2017;67(2):224–236.
4. Silva CMD, Peder LD, Thomazella MV, Teixeira JJV, Bertolini DA. Profile of HCV genotypes and HIV-subtypes among HIV-coinfected patients in southern Brazil. Arq Gastroenterol. 2019;56(4):344–350.
5. Freitas SZ, Teles SA, Lorenzo PC, et al. HIV and HCV coinfection: prevalence, associated factors and genotype characterization in the Midwest Region of Brazil. Rev Inst Med Trop Sao Paulo. 2014;56(6):517–524.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献