Immunity to Vaccine-Preventable Infections in Healthcare Professionals Working in Infectious Diseases Hospitals

Author:

Samodova O. V.1ORCID,Krieger E. A.1,Rogushina N. L.1

Affiliation:

1. Northern state medical university

Abstract

Relevance. During the ongoing pandemic of a new coronavirus infection (COVID-19), assessment of humoral immunity to vaccine preventable diseases in healthcare workers is crucial to estimate the risk of healthcare-associated infections. Aim. To assess the humoral immunity to vaccine-preventable diseases: whooping cough, influenza A, viral hepatitis A and B, new coronavirus infection (COVID-19), in healthcare professionals working with infectious patients. Materials and methods. We conducted a cross-sectional study enrolling 252 healthcare workers, which included a survey and assessment of immunoglobulins G to Bordetella pertussis, influenza A virus, hepatitis A virus, HBsAg and HBcAg of hepatitis B virus, and SARS- COV-2 by enzyme immunoassay. Results. The proportion of healthcare workers seronegative to pertussis was 46.8%, to influenza – 31.4%, to hepatitis A – 52.4%, to hepatitis B – 27.5%, to the SARS-CoV-2 virus – 29.8%. In 8.0% of cases the level of antibodies to Bordetella pertussis indicated a recent infection. The largest proportion of seronegative to pertussis (55.2%) was among individuals younger than 30 years. More than 80% of healthcare workers were vaccinated against seasonal influenza A during the previous year, 67.6% of them were seropositive. More than half (51.8%) of vaccinated but seronegative to influenza A health workers were older than 50 years. The odds of being seropositive to influenza A decreased with age, while the odds of being seropositive for viral hepatitis A increased with age. Vaccination against viral hepatitis B was received by 86.9% of people, 78.5% of them were seropositive to HBsAg, the remaining 21.5% needed revaccination. The proportion of healthcare workers seropositive for the SARS-CoV-2 virus was 57.5%, equivocal results were obtained in 12.7% of cases. The proportion of seronegative among those who had previously had COVID-19 was 40%, while among those who were vaccinated – 17.4%. Conclusion. The study showed a complex assessment of humoral immunity to the most common vaccine-preventable diseases: pertussis, influenza A, viral hepatitis А, B and novel coronavirus infection (COVID-19) in healthcare workers during the ongoing pandemic and allowed to make the following conclusions: 1. The proportion of healthcare workers susceptible to pertussis was 46.8% that required regular vaccination/revaccination of the seronegative healthcare workers to reduce the risk of infections healthcare-associated infections. 2. The proportion of healthcare workers vaccinated against influenza was 80% and exceeded the proportion of seropositive – 68.7%. 3. The proportion of healthcare workers seronegative to viral hepatitis B was 27.5%, to viral hepatitis A – 52.4%. 4. The COVID-19 seroprevalence among healthcare workers was 57.5%, regardless of whether it was obtained naturally or via vaccination. The proportion of seronegative healthcare workers among those having COVID-19 was 40%, among vaccinated – 17.4%, which confirms the necessity of vaccination / revaccination either after the infection or after the vaccination.

Publisher

LLC Numicom

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,Epidemiology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3