Affiliation:
1. Central Research Institute of Epidemiology
2. National Research Centre for Epidemiology and Microbiology Named After the Honorary Academician N.F. Gamaleya
3. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, of the Ministry of Health of the Russian Federation
4. Federal State Autonomous Institution "National Medical Research Center «Treatment and Rehabilitation Center»
Abstract
Relevance. Hepatitis B is a global problem of global and Russian public health due to its high prevalence and the possibility of forming a chronic form of the disease with the development of cirrhosis and hepatocellular carcinoma. Aims. Assessment of the herd immunity to hepatitis B in the population of the Russian Federation in 2017‒2019.Materials and methods. The research was carried out at the Central Institute of Epidemiology within the framework of a large-scale program to assess herd immunity to hepatitis B in the population of the Russian Federation. The results of studies for the presence of anti-HBs in various subjects of the Russian Federation in 2017 to 2019, which were performed in accordance with MU 3.1.2943-11, were analyzed. Additionally, as a reference study in 2020, a survey of donors in Moscow (n = 427) was conducted for the presence of anti-HBs. Standard methods of descriptive statistics Microsoft Excel and STATISTICA 12.0 (StatSoft, USA) were used for statistical processing. The mean values were estimated taking into account the 95% confidence interval [95% CI] (according to the Klopper-Pearson method (exact method).Results. The average annual values of the proportion of persons with protective immunity against hepatitis B for 2017, 2018 and 2019 were 70.03%, 67.95% and 66.36%, respectively. Significant differences were revealed in the average values of the proportion of persons with a protective level of anti-HBs in the Federal Districts (FD): higher than the average Russian indicators were found in the Northwestern (74.2%), Southern (71.0%) and Far Eastern FD (70.7%). In 44 subjects of the Russian Federation during the observation period, the proportion of persons with protective immunity against hepatitis B was less than 60%.Conclusion. The necessity of optimizing the system of serological monitoring of post-vaccination immunity against hepatitis B is substantiated, which will increase the effectiveness of preventive measures nationwide
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health,Epidemiology
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