Problematic Aspects of the Evaluation of the Epidemiological Effectiveness of Vaccination against Tick-BORNE Encephalitis-Reference-Cited by-同舟云学术

Problematic Aspects of the Evaluation of the Epidemiological Effectiveness of Vaccination against Tick-BORNE Encephalitis

Published:2018-10-23 Issue:5 Volume:17 Page:78-88
ISSN:2619-0494
Container-title:Epidemiology and Vaccine Prevention
language:
Short-container-title:Epidemiology and Vaccine Prevention

Author:

Penyevskaya N. A.¹,Rudakov N. V.¹,Rudakova S. A.²

Affiliation:

1. Omsk Research Institute of Natural Focal Infections; Omsk State Medical University

2. Omsk Research Institute of Natural Focal Infections

Abstract

This review analyzes the methodological reasons for the heterogeneity of the results of the evaluation of the epidemiological effectiveness of vaccine prophylaxis of tick-borne encephalitis (TBE) using indicators such as the efficiency coefficient (COEF) and the efficiency index (IEF), and their discrepancy with similar indicators of the immunological effectiveness of vaccines. It is shown that the calculation of COEF and IEF according to official statistical reporting is illegal in connection with the emergence of systematic errors of selection due to the impossibility of retrospective formation of compared groups of vaccinated and unvaccinated, comparable in risk of infection and disease. In addition, COEF and IEF do not allow to compare the efficiency of vaccination in different areas in physical and monetary units.Based on the analysis of the literature data on immunogenicity of modern vaccines against TBE, protective titer of antibodies and results of field tests of vaccine efficacy in the conditions of total coverage of the population with vaccinations, the authors conclude that the third generation vaccines against TBE protect against disease 95–98% of persons attacked by ticks. Algorithm for calculating the number of preventable cases of TBE diseases is proposed for a comparative evaluation of the effectiveness of vaccination as an anti-epidemic measure in different areas.

Publisher

LLC Numicom

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,Epidemiology

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