Maurice Raynaud (1834–1881) und das Mysterium „Raynaud-Phänomen“
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Published:2019-12
Issue:25
Volume:144
Page:1778-1783
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ISSN:0012-0472
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Container-title:DMW - Deutsche Medizinische Wochenschrift
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language:de
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Short-container-title:Dtsch med Wochenschr
Author:
Koehler Ulrich,Portig Irene,Hildebrandt Olaf,Koehler Niklas Alexander
Abstract
AbstractMaurice Raynaud first described color changes and symptoms of the fingers due to cold-induced vasospasm and restricted blood flow in his medical school thesis in 1862. Raynaud’s phenomenon is common and exists as an uncomplicated primary Raynaud phenomenon and a Raynaud phenomenon secondary to underlying diseases and medication. Mechanisms contributing to altered vasoconstrictor activity are endothelial and not-endothelial. Cold-induced vasospasm is probably a thermoregulatory problem and effects are mediated by sympathetic activity and selective stimulation of alpha2c-adrenoreceptors.
Publisher
Georg Thieme Verlag KG