Affiliation:
1. Department of Pharmacy, COMSATS University Islamabad, Abbottabad
Campus, COMSATS University Islamabad, Abbottabad, Pakistan
2. Department of Community Medicine, Ayub Medical College, Abbottabad,
Pakistan
Abstract
AbstractProton pump inhibitors (PPI) are commonly prescribed medications for a variety of
gastrointestinal disorders around the globe. Long-term utilization of proton
pump inhibitors is linked with different adverse events. Although, short-term
therapy has been demonstrated to have little or no impact on endocrine hormones
in men, yet its safety with long-term use has poorly been studied. We aimed to
evaluate the impacts of long-term utilization of proton pump inhibitors on male
reproductive hormones and its clinical outcomes. A cross-sectional study was
performed in two out-patients gastroenterology clinics in Khyber Pakhtunkhwa
province. Male patients who were using PPIs regularly for≥3 months were
enrolled in this study. Among 65 enrolled participants, patients with sexual
complaints have significant variations in mean serum levels of prolactin
(p<0.001), sex hormone binding globulins (p=0.043), total
testosterone (p<0.001) and progesterone (p=0.001) as compared to
patients without sexual complaints. Significantly high values of prolactin mean
ranks were observed in patient with sexual complaints (p<0.001). There
were statistically significant correlations of serum levels of sex hormone
binding globulins (p=0.003), total testosterone (p=0.008) and
progesterone (p<0.001) with serum prolactin levels. Similarly,
statistically significant variation was observed for decreased libido
(p=0.001), erectile dysfunction (p=0.001) and decreased semen
mass ((p<0.001) between normal and hyperprolactinemic PPI users. Highly
significant differences were observed in serum sex hormone binding globulins
(p<0.001), total testosterone (p<0.001) and progesterone
(p<0.001) values in normal and hyperprolactinemic groups. In conclusion,
long-term utilization of PPI may induce endocrine hormone disruption with
subsequent sexual complications.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism