Affiliation:
1. Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh,
India
Abstract
AbstractAn experiment was conducted to evaluate the compatibility of menatetrenone with
selected pharmaceutical excipients. Fourier Transform Infrared Spectroscopy
(FTIR) was used to assess drug-excipient compatibility. The present research
systematically investigates the FTIR spectrum of each chemical compound
separately and their physical blends, analyzing for possible shifts, alterations
or novel peak that may indicate chemical interactions. This study aims to
utilize spectral data interpretation to detect potential compatibility problems
that may occur while design and production of menatetrenone containing dosage
forms ensuring their increased stability and effectiveness. The FTIR results
demonstrated that all the pharmaceutical excipients were compatible with
menatetrenone. In conclusion, the compatibility of pharmaceutical excipients
with menatetrenone was successfully assessed using FTIR that will aid in future
design of formulations containing menatetrenone as therapeutic moiety.