Advances in Exploring Cyclopentadienyl (Cp) Rhodium Catalysts Featuring Diastereotopic or Enantiotopic Cp Faces for Asymmetric C

Advances in Exploring Cyclopentadienyl (Cp) Rhodium Catalysts Featuring Diastereotopic or Enantiotopic Cp Faces for Asymmetric C–H Activation

Published:2023-01-02 Issue:09 Volume:55 Page:1309-1321
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Wang Jun¹²,Yan Xiaoqiang¹²

Affiliation:

1. Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University

2. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, Sun Yat-Sen University

Abstract

AbstractChiral cyclopentadienyl rhodium (CpRh) complexes have emerged as a class of powerful catalysts for enantioselective C–H activation reactions. In terms of Cp ligand development, the mainstream is to design chiral ligands with C 2 symmetry in order to avoid the problem of Cp face selectivity during their metalation with rhodium. In recent years, CpRh catalysts with diastereotopic or enantiotopic Cp faces were also revealed and successfully applied in asymmetric C–H activation. These advances are summarized in this short review together with perspectives for their future development.1 Introduction2 Cp Ligands with Diastereotopic Cp Faces3 Cp Ligands with Enantiotopic Cp Faces4 Conclusion and Outlook

Funder

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2005-5006.pdf

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