Affiliation:
1. Department of Pharmacology, Raj Kumar Goel Institute of Technology
(Pharmacy), Ghaziabad, Uttar Pradesh, India
Abstract
Abstract
Introduction It is an indubitable fact that vaccination has been
instrumental in the eradication and prevention of the deadliest diseases
worldwide. Continuous vaccine safety surveillance is helpful to counter the
negative perception and thus allay the fear of Adverse Events Following
Immunization (AEFI) in the general public. VigiAccess, the WHO global database
of reported side effects of medicinal products, can be accessed by the public at
large. The objective of this study is to assess the characteristics of AEFIs of
the commonly used vaccines in children in VigiAccess.
Materials and Methods VigiAccess was thoroughly explored for the
categories, number, and types of AEFIs of commonly used vaccines among children
that are reported in five continents between 2011 and 2021.
Results After a comprehensive analysis in VigiAccess, 27 kinds of AEFIs
were discovered. For the nine vaccines, a total of 1,412,339 AEFIs were found.
The most prevalent AEFIs were general disorder and administration site condition
(436,199 or 30%). The majority of AEFIs are found in America, with
Europe, Oceania, Asia, and Africa following closely behind. Girls of age from 27
days to 23 months had the highest number of AEFIs. The highest number of AEFIs
was recorded in the year 2018.
Conclusion America has the maximum, whilst Africa has the least AEFI. Few
AEFIs were caused by the measles vaccination, while the majority were related to
the general disorder and administration site condition. Data synchronization in
VigiAccess needs to be enhanced to improve its dependability.
Subject
Drug Discovery,General Medicine