Low Concentration of Lipoprotein(a) is an Independent Predictor of Incident Type 2 Diabetes-Reference-Cited by-同舟云学术

Low Concentration of Lipoprotein(a) is an Independent Predictor of Incident Type 2 Diabetes

Published:2024-05-21 Issue:07 Volume:56 Page:504-508
ISSN:0018-5043
Container-title:Hormone and Metabolic Research
language:en
Short-container-title:Horm Metab Res

Author:

Liu Wenhao¹,Zhang Guanzhao¹,Nie Zifan¹,Guan Xiangfeng²,Sun Tingting²,Jin Xiaodong³,Li Bo¹

Affiliation:

1. Cardiology, Zibo Central Hospital, Zibo, China

2. Cardiology, Shandong Second Medical University, Weifang, China

3. Geriatric Medicine, Zibo Central Hospital, Zibo, China

Abstract

AbstractThe aim of the study was to assess the association between lipoprotein(a) [Lp(a)] concentration and incident type 2 diabetes. A meta-analysis of qualified studies on the relationship of low levels of Lp(a) concentration with incident type 2 diabetes was conducted. PubMed and Cochrane libraries were searched for randomized controlled trials containing data on events. Seven randomized trials with 227178 subjects were included in this analysis. We found an inverse association of the levels of Lp(a) concentration with risk of type 2 diabetes with approximately 37% lower relative risk in the group with the highest concentration compared with group with the lowest concentration. The current available evidence from prospective studies suggests that there is an inverse association between the levels of Lp(a) concentration and risk of type 2 diabetes, with a higher risk of type 2 diabetes at low levels of Lp(a) concentration. Therefore, we believe that the low levels of Lp(a) concentration is an independent predictor of incident type 2 diabetes.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Georg Thieme Verlag KG

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2316-9124.pdf

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